检索范围:
排序: 展示方式:
null
《医学前沿(英文)》 2011年 第5卷 第1期 页码 45-52 doi: 10.1007/s11684-011-0117-y
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia. In past decades, intensive studies on the biology and treatment of this disease have resulted in a remarkably thorough understanding of its pathogenesis and improvement of treatment outcomes. In particular, the introduction of all-trans retinoic acid to conventional chemotherapy improved dramatically the remission and survival rates of APL patients and consequently became the major treatment modality for it. In the last decade, the groundbreaking development of arsenic further improved the survival rate of APL patients. As the most active agent in APL, arsenic directly degrades the PML-RARα fusion transcript, leading to the differentiation and apoptosis of leukemia cells and the potential eradication of APL leukemia-initiating cells (LICs), thus making the disease a potentially curable type of leukemia. More notably, the recent development of oral arsenic compounds may further enhance not only clinical outcomes but also the convenience of patients, which may dramatically change the APL clinical scenario in the near future.
关键词: acute promyelocytic leukemia arsenic all-trans retinoic acid survival
Current treatment strategy of acute promyelocytic leukemia
Jianqing Mi
《医学前沿(英文)》 2011年 第5卷 第4期 页码 341-347 doi: 10.1007/s11684-011-0169-z
关键词:
acute promyelocytic leukemia
all-
Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8
Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN
《医学前沿(英文)》 2009年 第3卷 第1期 页码 61-66 doi: 10.1007/s11684-009-0007-8
钱七虎,何益寿
《中国工程科学》 2001年 第3卷 第5期 页码 32-34
长江越江交通通道工程对我国21世纪经济的稳定发展作用巨大,因此在越江交通通道工程方案的选择上不能唯桥是举,而要因地制宜和恰到好处地发挥桥梁和水下隧道各自的优势,总体上实行桥隧并举。
null
《医学前沿(英文)》 2016年 第10卷 第3期 页码 311-319 doi: 10.1007/s11684-016-0460-0
We evaluated the roles of calpain cleavage-related mutations of the integrin β3 cytoplasmic tail in integrin αIIbβ3 bidirectional signaling using a trans-dominant inhibition model. Chimeric Tac-β3 proteins (i.e., Tac-β3, Tac-β3D741, Tac-β3D747, Tac-β3D754, Tac-β3D759, and Tac-β3DNITY) consisting of the extracellular and transmembrane domains of human IL-2 receptor (Tac) and the human integrin β3 cytoplasmic domain were stably expressed in the 123 CHO cells harboring human glycoprotein Ib-IX and wild-type integrin αIIbβ3. The different cells were assayed for stable adhesion and spreading on immobilized fibrinogen, and for binding soluble fibrinogen representing outside-in and inside-out signaling events, respectively. The chimeric protein Tac-β3 inhibited, and Tac-β3DNITY partially attenuated stable adhesion and spreading. Tac-β3, Tac-β3D759, Tac-β3DNITY, and Tac-β3D754, but not Tac-β3D747 or Tac-β3D741, impaired the soluble fibrinogen binding. Results indicated that the bidirectional signaling was significantly inhibited by Tac-β3 and Tac-β3DNITY, albeit to a much lesser extent. Moreover, only inside-out signaling was impaired in the 123/Tac-β3D759 and 123/Tac-β3D754 cells in contrast to an intact bidirectional signaling in the 123/Tac-β3D747 and 123/Tac-β3D741 cells. In conclusion, the calpain cleavage of integrin β3 resulted in the regulatory effects on signaling by interrupting its interaction with cytoplasmic proteins rather than altering its conformation, and may thus regulate platelet function.
关键词: integrin β3 signal transduction trans-dominant inhibition model
Engineering Management to Serve All Human Beings
Yong-fu Sun
《工程管理前沿(英文)》 2014年 第1卷 第3期 页码 231-231 doi: 10.15302/J-FEM-2014032
《化学科学与工程前沿(英文)》 2023年 第17卷 第5期 页码 516-524 doi: 10.1007/s11705-022-2238-z
关键词: all inorganic perovskite solar cells graphene oxide quantum dots high performance stability
《医学前沿(英文)》 2021年 第15卷 第3期 页码 416-437 doi: 10.1007/s11684-021-0852-7
关键词: surgical aortic valve replacement trans-catheter aortic valve implantation left ventricular hypertrophy and fibrosis myocardial force-velocity relationship His-Purkinje pacing renin-angiotensin system inhibitors coronary access impairment
《医学前沿(英文)》 2022年 第16卷 第1期 页码 102-110 doi: 10.1007/s11684-021-0850-9
关键词: COVID-19 RAS inhibitor hypertension all-cause mortality
“ALL FREE” — a novel design concept of applying partial oxidation process to vehicle
Ling LIN, Wenshuang LIN, Qingbiao LI, Yao ZHOU,
《化学科学与工程前沿(英文)》 2010年 第4卷 第2期 页码 207-212 doi: 10.1007/s11705-009-0240-3
关键词: oxidation process CO complete oxidation ALL FREE -butane
脂肪变性诱发肝癌发生机制——HCV核心基因转基因小鼠的经验教训 Review
Pan Diao, Fangping Jia, Xiaojing Wang, Xiao Hu, Takefumi Kimura, Takero Nakajima, Toshifumi Aoyama, Kyoji Moriya, Kazuhiko Koike, Naoki Tanaka
《工程(英文)》 2021年 第7卷 第12期 页码 1797-1805 doi: 10.1016/j.eng.2021.08.019
丙型肝炎病毒(HCV)感染是全球慢性肝炎、肝硬化和肝细胞癌(HCC)的主要病因。在HCV的结构蛋白中,HCV核心蛋白具有调控基因转录、脂质代谢、细胞增殖、细胞凋亡和自噬的能力,所有这些都与HCC的发展密切相关。携带HCV核心基因的转基因小鼠表现出与慢性丙型肝炎患者的临床特征相似的年龄依赖性胰岛素抵抗、肝脂肪变性和HCC。一些饮食习惯的调整,包括限制热量和富含饱和脂肪酸(SFA)、反式脂肪酸(TFA)或胆固醇的饮食,被证明会影响HCV核心基因转基因小鼠的肝脏脂肪生成和肿瘤形成。这些饮食的改变除了调节肝纤维化过程和微环境外,还调节了肝细胞的应激和增殖,从而证实了饮
食习惯与脂肪变性相关的肝癌发生之间的密切联系。本文综述了HCV基因组转基因小鼠模型的研究结果,重点介绍了HCV核心基因转基因小鼠的研究结果,并讨论了HCV核心蛋白诱导脂肪变性和肝癌发生的机制,以及饮食习惯对脂肪变性所致肝癌的影响。
Primary health care for all by 2020: The systematic reform of the medical and health system in China
《医学前沿(英文)》 2010年 第4卷 第1期 页码 3-7 doi: 10.1007/s11684-010-0024-7
郭健
《中国工程科学》 2010年 第12卷 第7期 页码 90-95
以舟山大陆连岛工程为背景,阐述和讨论了在跨海大桥中开展健康监测的重要性和研究现状,并分析了跨海大桥健康监测和损伤识别所面临的关键技术问题和研究趋势,提出了考虑非线性效应和荷载激励特征来开展复杂结构损伤识别的研究思路,以提升通过大型健康监测系统来实现桥梁损伤评估的能力。
用于超快电子器件的全通型波导 Article
Desong Wang, Ke Wu
《工程(英文)》 2023年 第30卷 第11期 页码 49-54 doi: 10.1016/j.eng.2023.04.005
Ultrashort pulse transmission has been recognized as a primary problem that fundamentally hinders the development of ultrafast electronics beyond the current nanosecond timescale. This requires a transmission line or waveguide that exhibits an all-pass frequency behavior for the transmitted ultrashort pulse signals. However, this type of waveguiding structure has not yet been practically developed; groundbreaking innovations and advances in signal transmission technology are urgently required to address this scenario. Herein, we present a synthesized all-pass waveguide that demonstrates record guided-wave controlling capabilities, including eigenmode reshaping, polarization rotation, loss reduction, and dispersion improvement. We experimentally developed two waveguides for use in ultrabroad frequency ranges (direct current (DC)-to-millimeter-wave and DC-to-terahertz). Our results suggest that the waveguides can efficiently transmit picosecond electrical pulses while maintaining signal integrity. This waveguide technology is an important breakthrough in the evolution of ultrafast electronics, providing a path towards frequency-engineered ultrashort pulses for low-loss and low-dispersion transmissions.
关键词: All-pass waveguide Ultrashort pulse Picosecond transmission Ultrafast electronics Terahertz technology Mode-selective transmission line
Selective pseudosolubilization capability of
Fei HUA, Hongqi WANG
《环境科学与工程前沿(英文)》 2013年 第7卷 第4期 页码 539-551 doi: 10.1007/s11783-013-0498-z
关键词:
标题 作者 时间 类型 操作
Arsenic in the treatment of newly diagnosed acute promyelocytic leukemia: current status and future research direction
null
期刊论文
Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8
Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN
期刊论文
Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition
null
期刊论文
Enhanced charge extraction for all-inorganic perovskite solar cells by graphene oxide quantum dots modified
期刊论文
opportunities in improving left ventricular remodelling and clinical outcome following surgical and trans-catheter
期刊论文
Renin--angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID
期刊论文
“ALL FREE” — a novel design concept of applying partial oxidation process to vehicle
Ling LIN, Wenshuang LIN, Qingbiao LI, Yao ZHOU,
期刊论文
脂肪变性诱发肝癌发生机制——HCV核心基因转基因小鼠的经验教训
Pan Diao, Fangping Jia, Xiaojing Wang, Xiao Hu, Takefumi Kimura, Takero Nakajima, Toshifumi Aoyama, Kyoji Moriya, Kazuhiko Koike, Naoki Tanaka
期刊论文
Primary health care for all by 2020: The systematic reform of the medical and health system in China
期刊论文